Increased diffusivity in acute multiple sclerosis lesions predicts risk of black hole.

ABSTRACT:

Objective

Diffusion tensor imaging (DTI) quantifies Brownian motion of water within tissue. Inflammation leads to tissue injury, resulting in increased diffusivity and decreased directionality. We hypothesize that DTI can quantify the damage within acute multiple sclerosis (MS) white matter lesions to predict gadolinium (Gd)-enhancing lesions that will persist 12 months later as T1 hypointensities.

Methods

A cohort of 22 individuals underwent 7 brain MRI scans over 15 months. DTI parameters were temporally quantified within regions of Gd enhancement. Comparison to the homologous region in the hemisphere contralateral to the Gd-enhancing lesion was also performed to standardize individual lesion DTI parameters.

Results

After classifying each Gd-enhancing region as to b

SUBMITTER: Naismith RT 

PROVIDER: S-EPMC2882210 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature