Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.

ABSTRACT:

Background

Cellular cholesterol is a vital component of the cell membrane. Its concentration is tightly controlled by mechanisms that remain only partially characterized. In this study, we describe a late endosome/lysosomes-associated protein whose expression level affects cellular free cholesterol content.

Methodology/principal findings

Using a restricted proteomic analysis of detergent-resistant membranes (DRMs), we have identified a protein encoded by gene C11orf59. It is mainly localized to late endosome/lysosome (LE/LY) compartment through N-terminal myristoylation and palmitoylation. We named it Pdro for protein associated with DRMs and endosomes. Very recently, three studies have reported on the same protein under two other names: the human p27RF-Rho that regulates Rh

SUBMITTER: Guillaumot P 

PROVIDER: S-EPMC2882324 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature