High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance.

ABSTRACT: Acquired drug resistance represents a frequent obstacle which hampers efficient chemotherapy of cancers. The contribution of aberrant DNA methylation to the development of drug resistant tumor cells has gained increasing attention over the past decades. Hence, the objective of the presented study was to characterize DNA methylation changes which arise from treatment of tumor cells with the chemotherapeutic drug doxorubicin. DNA methylation levels from CpG islands (CGIs) linked to twenty-eight genes, whose expression levels had previously been shown to contribute to resistance against DNA double strand break inducing drugs or tumor progression in different cancer types were analyzed. High-definition DNA methylation profiles which consisted of methylation levels from 800 CpG sites mapping to

SUBMITTER: Boettcher M 

PROVIDER: S-EPMC2882327 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature