Genetic determinants of immune-response to a polysaccharide vaccine for typhoid.

ABSTRACT:

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Differences in immunological response among vaccine recipients are determined both by their genetic differences and environmental factors. Knowledge of genetic determinants of immunological response to a vaccine can be used to design a vaccine that circumvents immunogenetic restrictions. The currently available vaccine for typhoid is a pure polysaccharide vaccine, immune response to which is T-cell independent. Little is known about whether genetic variation among vaccinees associates with variation in their antibody response to a polysaccharide vaccine. We conducted a study on 1,000 individuals resident in an area at high-risk for typhoid; vaccinated them with the typhoid vaccine, measured their antibody response to the vaccine, assayed >2,000 curated SNPs chosen from 2

SUBMITTER: Majumder PP 

PROVIDER: S-EPMC2882648 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature