Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study.

ABSTRACT:

Objective

To examine the long-term safety and efficacy of three antipsychotics in early-onset schizophrenia spectrum disorders.

Method

Patients (8 to 19 years old) who had improved during an 8-week, randomized, double-blind acute trial of olanzapine, risperidone, or molindone (plus benztropine) were eligible to continue on the same medication for up to 44 additional weeks under double-blind conditions. Adjunctive medications were allowed according to defined algorithms. Standardized symptom, safety, and functional assessments were conducted every 4 weeks.

Results

Of the 116 youths randomized in the acute trial, 54 entered maintenance treatment (molindone, n = 20; olanzapine, n = 13; risperidone, n = 21). Fourteen (26%) completed 44 weeks of treatment. Adverse effects

SUBMITTER: Findling RL 

PROVIDER: S-EPMC2882800 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature