Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.

ABSTRACT:

Background

Hookworm infection is one of the most important neglected diseases in developing countries, with approximately 1 billion people infected worldwide. To better understand hookworm biology and nematode parasitism, the present study generated a near complete transcriptome of the canine hookworm Ancylostoma caninum to a very high coverage using high throughput technology, and compared it to those of the free-living nematode Caenorhabditis elegans and the parasite Brugia malayi.

Results

The generated transcripts from four developmental stages, infective L3, serum stimulated L3, adult male and adult female, covered 93% of the A. caninum transcriptome. The broad diversity among nematode transcriptomes was confirmed, and an impact of parasitic adaptation on transcriptome d

SUBMITTER: Wang Z 

PROVIDER: S-EPMC2882930 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature