Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss.

ABSTRACT:

Background

In obesity, impaired adipose tissue function may promote secondary disease through ectopic lipid accumulation and excess release of adipokines, resulting in systemic low-grade inflammation, insulin resistance and organ dysfunction. However, several of the genes regulating adipose tissue function in obesity are yet to be identified.

Methodology/principal findings

In order to identify novel candidate genes that may regulate adipose tissue function, we analyzed global gene expression in abdominal subcutaneous adipose tissue before and one year after bariatric surgery (biliopancreatic diversion with duodenal switch, BPD/DS) (n = 16). Adipose tissue from lean healthy individuals was also analyzed (n = 13). Two different microarray platforms (AB 1700 and Illumina) were

SUBMITTER: Dankel SN 

PROVIDER: S-EPMC2882947 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature