Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer.

ABSTRACT:

Background

Wolbachia are among the most abundant symbiotic microbes on earth; they are present in about 66% of all insect species, some spiders, mites and crustaceans, and most filarial nematode species. Infected filarial nematodes, including many pathogens of medical and veterinary importance, depend on Wolbachia for proper development and survival. The mechanisms behind this interdependence are not understood. Interestingly, a minority of filarial species examined to date are naturally Wolbachia-free.

Methodology/principal findings

We used 454 pyrosequencing to survey the genomes of two distantly related Wolbachia-free filarial species, Acanthocheilonema viteae and Onchocerca flexuosa. This screen identified 49 Wolbachia-like DNA sequences in A. viteae and 114 in O. flexuo

SUBMITTER: McNulty SN 

PROVIDER: S-EPMC2882956 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature