Cancer risk in DES daughters.

ABSTRACT:

Objective

We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero.

Methods

A total of 12,091 DES-exposed women in the Netherlands were followed prospectively from December 1992 till June 2008. Cancer incidence was assessed through linkage with the Dutch pathology database (PALGA) and the Netherlands Cancer Registry and compared with the Dutch female population.

Results

A total of 348 medically verified cancers occurred; median age at end of follow-up was 44.0 years. No overall increased risk of cancer was found (standardized incidence ratio [SIR] = 1.01; 95% confidence interval [CI] = 0.91, 1.13). The risk of clear cell adenocarcinoma of the vagina and cervix (CCA) was statistically significantly increased (SIR = 24.23; 95% CI = 8.89

SUBMITTER: Verloop J 

PROVIDER: S-EPMC2883094 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature