Susceptibility genes in common complex kidney disease.

ABSTRACT:

Purpose of review

This paper reviews recent efforts to identify genetic variants conferring risk for chronic kidney disease. A brief overview of methods for identifying gene variants is provided, along with genetic associations and new avenues under exploration.

Recent findings

The role of renal failure susceptibility genes, including MYH9, ELMO1, UMOD and ACTN4, has become clearer over the past 18 months. The spectrum of MYH9-associated kidney disease, including focal segmental glomerulosclerosis, global glomerulosclerosis and collapsing glomerulopathy, related entities contributing to approximately 43% of end-stage renal disease in African-Americans, has come to light.

Summary

MYH9 will re-categorize focal segmental glomerulosclerosis and related disorders, and has

SUBMITTER: Divers J 

PROVIDER: S-EPMC2883259 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature