Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.

ABSTRACT:

Background/aims

Seven genomic loci, implicated by single nucleotide polymorphisms (SNPs), have recently been associated with progression to advanced fibrosis (fibrosis risk) in patients with chronic hepatitis C virus. Other variants in these loci have not been examined but may be associated with fibrosis risk independently of or due to linkage disequilibrium with the original polymorphisms.

Methods

We carried out dense genotyping and association testing of additional SNPs in each of the 7 regions in Caucasian case control samples.

Results

We identified several SNPs in the toll-like receptor 4 (TLR4) and syntaxin binding protein 5-like (STXBP5L) loci that were associated with fibrosis risk independently of the original significant SNPs. Haplotypes consisting of these S

SUBMITTER: Li Y 

PROVIDER: S-EPMC2883297 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature