Dynamic calibration of pharmacokinetic parameters in dose-finding studies.

ABSTRACT: We introduce a dose-finding algorithm to be used to identify a level of dose that corresponds to some given targeted response. Our motivation arises from problems where the response is a continuously measured quantity, typically some pharmacokinetic parameter. We consider the case where an agreed level of response has been determined from earlier studies on some population and the purpose of the current trial is to obtain the same, or a comparable, level of response in a new population. This relates to bridging studies. The example driving our interest comes from studies on drugs for HIV that have already been evaluated in adults and where the new studies are to be carried out in children. These drugs have the ability to produce some given mean pharmacokinetic response in the adult populat

SUBMITTER: O'Quigley J 

PROVIDER: S-EPMC2883303 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature