Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma.

ABSTRACT: The majority of women diagnosed with epithelial ovarian carcinoma (EOC) succumb due to complications of metastatic disease, suggesting that antimetastatic therapies may improve patient survival. EOC metastasis involves intraperitoneal shedding of cells from the primary tumor, followed by adhesion and localized penetration of the submesothelial matrix to anchor metastatic implants. Accumulation of malignant ascites is also common. Thus, a unique microenvironmental niche is established, which includes malignant cells and a plethora of soluble factors secreted by-or in response to-tumor cells. As cells penetrating the submesothelial surface encounter an interstitial collagen-rich extracellular matrix, we have used three-dimensional type I collagen gels to model early events resulting from int

SUBMITTER: Barbolina MV 

PROVIDER: S-EPMC2883461 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature