Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.

ABSTRACT:

Background & aims

The corticotrophin-releasing hormone (CRH) family of peptides modulates intestinal inflammation and the CRH receptor 2 (CRHR2) suppresses postnatal angiogenesis in mice. We investigated the functions of CRHR1 and CRHR2 signaling during intestinal inflammation and angiogenesis.

Methods

The activities of CRHR1 and CRHR2 were disrupted by genetic deletion in mice or with selective antagonists. A combination of in vivo, ex vivo, and in vitro measures of angiogenesis were used to determine their activity. CRHR1(-/-) mice and CRHR2(-/-) mice with dextran sodium sulfate-induced colitis were analyzed in comparison with wild-type littermates (controls).

Results

Colitis was significantly reduced in mice in which CRHR1 activity was disrupted by genetic deletion

SUBMITTER: Im E 

PROVIDER: S-EPMC2883634 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature