Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity.

ABSTRACT:

Background & aims

Surgical intervention produces sustainable weight loss and metabolic improvement in obese individuals. Vertical sleeve gastrectomy (VSG) produces dramatic, sustained weight loss; we investigated whether these changes result from improved sensitivity to leptin.

Methods

VSG was performed in Long-Evans rats with diet-induced obesity. Naïve or sham-operated rats, fed either ad libitum or pair-fed with the VSG group, were used as controls. Following surgery, body weights and food intake were monitored. We investigated energy expenditure, meal patterns, leptin sensitivity, and expression of pro-opiomelanocortin/agouti-related peptide/neuropeptide Y in the hypothalamus of the rats.

Results

We observed sustained losses in weight and body fat in male and fema

SUBMITTER: Stefater MA 

PROVIDER: S-EPMC2883635 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature