Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.

ABSTRACT:

Background & aims

Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is effective in less than 50% of those infected with HCV genotype 1. Genome-wide association studies have linked response to PEG-IFN/RBV with common single nucleotide polymorphisms in the vicinity of interferon (IFN)-lambda genes on chromosome 19. We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients.

Methods

A cross-sectional study of 1021 consecutive patients enrolled in the Duke Hepatology Clinic Research Database and Biorepository. We analyzed DNA, clinical and demographic data, along with validated data of the response of 231 subjects to PEG-IFN

SUBMITTER: McCarthy JJ 

PROVIDER: S-EPMC2883666 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature