CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice.

ABSTRACT:

Background & aims

Gastroparesis is a well-recognized complication of diabetes. In diabetics, up-regulation of heme oxygenase-1 (HO1) in gastric macrophages protects against oxidative stress-induced damage. Loss of up-regulation of HO1, the subsequent increase in oxidative stress, and loss of Kit delays gastric emptying; this effect is reversed by induction of HO1. Macrophages have pro- and anti-inflammatory activities, depending on their phenotype. We investigated the number and phenotype of gastric macrophages in NOD/ShiLtJ (nonobese diabetic [NOD]) mice after onset of diabetes, when delayed gastric emptying develops, and after induction of HO1 to reverse delay.

Methods

Four groups of NOD and db/db mice were studied: nondiabetic, diabetic with normal emptying, diabetic with

SUBMITTER: Choi KM 

PROVIDER: S-EPMC2883675 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature