Ontology highlight
ABSTRACT:
SUBMITTER: Comas I
PROVIDER: S-EPMC2883744 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Comas Iñaki I Chakravartti Jaidip J Small Peter M PM Galagan James J Niemann Stefan S Kremer Kristin K Ernst Joel D JD Gagneux Sebastien S
Nature genetics 20100523 6
Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades. We sequenced the genomes of 21 strains representative of the global diversity and six major lineages of the M. tuberculosis complex (MTBC) at 40- to 90-fold coverage using Illumina next-generation DNA sequencing. We constructed a genome-wide phylogeny based on these genome sequences. Comparative analyses of the sequences showed, as expected, that essential genes in MTBC were more evolu ...[more]