A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease.

ABSTRACT:

Background & aims

Patients with baseline hepatitis C virus-RNA levels (bHCV-RNA)>6 log IU/mL or cirrhosis have a reduced probability of a sustained-virologic response (SVR). We examined the relation between bHCV-RNA, cirrhosis, and SVR with a mathematical model that includes the critical-drug efficacy (epsilonc; the efficacy required for a drug to clear HCV), the infection-rate constant (beta), and the percentage of HCV-infected hepatocytes (pi).

Methods

The relation between baseline factors and SVR was evaluated in 1000 in silico HCV-infected patients, generated by random assignment of realistic host and viral kinetic parameters. Model predictions were compared with clinical data from 170 noncirrhotic and 75 cirrhotic patients.

Results

The ranges chosen for beta and

SUBMITTER: Dahari H 

PROVIDER: S-EPMC2883911 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature