Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth.

ABSTRACT: When conditions are unfavorable, virtually all living cells have the capability of entering a resting state termed quiescence or G0. Many aspects of the quiescence program as well as the mechanisms governing the entry and exit from quiescence remain poorly understood. Previous studies using the budding yeast Saccharomyces cerevisiae have shown that upon entry into stationary phase, a quiescent cell population emerges that is heavier in density than nonquiescent cells. Here, we show that total intracellular trehalose and glycogen content exhibits substantial correlation with the density of individual cells both in stationary phase batch cultures and during continuous growth. During prolonged quiescence, trehalose stores are often maintained in favor over glycogen, perhaps to fulfill its num

SUBMITTER: Shi L 

PROVIDER: S-EPMC2883942 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature