Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.

ABSTRACT:

Objective

To examine the association between renin-angiotensin-aldosterone system (RAAS) genes and salt sensitivity of blood pressure (BP).

Methods

A 7-day low-sodium dietary intervention followed by a 7-day high-sodium dietary intervention was conducted among 1906 participants living in a rural region of north China where habitual sodium intake is high. BP measurements were obtained at baseline and following each intervention using a random-zero sphygmomanometer.

Results

DBP and mean arterial pressure responses increased with the number of rs4524238 A alleles in the angiotensin II receptor type 1 gene. For example, mean DBP responses (95% confidence interval) among those with genotypes G/G, G/A, and A/A were -2.53 (-2.89 to -2.18), -3.49 (-4.13 to -2.86), and -5.78 (

SUBMITTER: Gu D 

PROVIDER: S-EPMC2884148 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature