Phosphate and carbonate salts of calcium support robust bone building in osteoporosis.

ABSTRACT:

Background

Calcium is an essential cotherapy in osteoporosis treatment. The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance.

Objective

Our objective was to test the hypothesis that calcium phosphate would better support anabolic bone building than would calcium carbonate.

Design

This study was a 12-mo, randomized, positive-comparator, 2-arm, single-blind clinical trial in 211 patients treated with teriparatide who consumed <1000 mg phosphorus/d. Participants were randomly assigned to receive, in addition to teriparatide and 1000 IU cholecalciferol, 1800 mg calcium/d as either tricalcium phosphate or calcium carbonate. The primary endpo

SUBMITTER: Heaney RP 

PROVIDER: S-EPMC2884321 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature