The developmental expression dynamics of Drosophila melanogaster transcription factors.

ABSTRACT:

Background

Site-specific transcription factors (TFs) are coordinators of developmental and physiological gene expression programs. Their binding to cis-regulatory modules of target genes mediates the precise cell- and context-specific activation and repression of genes. The expression of TFs should therefore reflect the core expression program of each cell.

Results

We studied the expression dynamics of about 750 TFs using the available genomics resources in Drosophila melanogaster. We find that 95% of these TFs are expressed at some point during embryonic development, with a peak roughly between 10 and 12 hours after egg laying, the core stages of organogenesis. We address the differential utilization of DNA-binding domains in different developmental programs systematically

SUBMITTER: Adryan B 

PROVIDER: S-EPMC2884543 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature