Aging blunts the dynamics of vasodilation in isolated skeletal muscle resistance vessels.

ABSTRACT: Aging is associated with an altered ability to match oxygen delivery (QO2) to consumption ((.)VO2) in skeletal muscle and differences in the temporal profile of vasodilation may provide a mechanistic basis for the QO2-to-(.)VO2 mismatching during the rest-to-exercise transition. Therefore, we tested the hypothesis that the speed of vasodilation will be blunted in skeletal muscle first-order arterioles from old vs. young rats. Arterioles from the soleus and the red portion of the gastrocnemius (Gast(Red)) muscles were isolated from young (Y, 6 mo; n = 9) and old (O, 24 mo; n = 9) Fischer 344 rats and studied in vitro. Vessels were exposed to acetylcholine (ACh; 10(-6) M), sodium nitroprusside (SNP; 10(-4) M), and increased intraluminal flow, and the subsequent vasodilation was recorded at 3

SUBMITTER: Behnke BJ 

PROVIDER: S-EPMC2885069 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature