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Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.


ABSTRACT: This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.

SUBMITTER: Moore SM 

PROVIDER: S-EPMC2885287 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.

Moore Shelley M SM   Liang Tiebing T   Graves Tamara J TJ   McCall Kevin M KM   Carr Lucinda G LG   Ehlers Cindy L CL  

Human genomics 20090701 4


This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of  ...[more]

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