Association between EGF +61 G/A and glioma risk in a Chinese population.

ABSTRACT:

Background

Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variations of the EGF +61G/A (rs4444903) may lead to an alteration in EGF production and/or activity, which can result in individual susceptibility to brain glioma. The purpose of this study was to investigate the potential association between EGF +61G/A and brain glioma in a Chinese population.

Methods

In this study, we analyzed single nucleotide polymorphism of EGF +61G/A in 677 patients with glioma and 698 gender- and age-matched controls. Genotyping was performed by polymerase chain reaction-ligation detection reaction (PCR-LDR) method.

Results

The A all

SUBMITTER: Wang S 

PROVIDER: S-EPMC2885363 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature