Molecular photoacoustic tomography with colloidal nanobeacons.

ABSTRACT: Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

SUBMITTER: Pan D 

PROVIDER: S-EPMC2885454 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature