Neural origins of human sickness in interoceptive responses to inflammation.

ABSTRACT:

Background

Inflammation is associated with psychological, emotional, and behavioral disturbance, known as sickness behavior. Inflammatory cytokines are implicated in coordinating this central motivational reorientation accompanying peripheral immunologic responses to pathogens. Studies in rodents suggest an afferent interoceptive neural mechanism, although comparable data in humans are lacking.

Methods

In a double-blind, randomized crossover study, 16 healthy male volunteers received typhoid vaccination or saline (placebo) injection in two experimental sessions. Profile of Mood State questionnaires were completed at baseline and at 2 and 3 hours. Two hours after injection, participants performed a high-demand color word Stroop task during functional magnetic resonance imagin

SUBMITTER: Harrison NA 

PROVIDER: S-EPMC2885492 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature