A noninvasive imaging approach to assess plaque severity: the carotid atherosclerosis score.

ABSTRACT:

Background and purpose

The presence of IPH and/or FCR in the carotid atherosclerotic plaque indicates a high-risk lesion. The aim of this multicenter cross-sectional study was to establish the characteristics of lesions that may precede IPH and/or FCR. We further sought to construct a CAS that stratifies carotid disease severity.

Materials and methods

Three hundred forty-four individuals from 4 imaging centers with 16%-99% carotid stenosis by duplex sonography underwent carotid MR imaging. In approximately 60% of the study sample (training group), multivariate analysis was used to determine factors associated with IPH and FCR. Statistically significant parameters identified during multivariate analysis were used to construct CAS. CAS was then applied to the remaining arterie

SUBMITTER: Underhill HR 

PROVIDER: S-EPMC2885536 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature