Modified intention to treat reporting in randomised controlled trials: systematic review.

ABSTRACT:

Objectives

To determine the incidence and characteristics of randomised controlled trials that report using the modified intention to treat approach, and how the approach is described.

Design

Systematic review.

Data sources

PubMed, Embase, Cochrane central register of controlled trials, ISI Web of Knowledge, Ovid, HighWire Press, Science-Direct, Ingenta, Medscape, BioMed Central, Springer, and Wiley, from inception to December 2006.

Main outcome measures

Incidence of trials in which use of modified intention to treat was reported, and how the approach was described (classified according to the type and number of deviations from the intention to treat approach).

Results

475 randomised controlled trials reported use of a modified intention to treat analysi

SUBMITTER: Abraha I 

PROVIDER: S-EPMC2885592 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature