From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.

ABSTRACT: Comparative genomics is the cornerstone of identification of gene functions. The immense number of living organisms precludes experimental identification of functions except in a handful of model organisms. The bacterial domain is split into large branches, among which the Firmicutes occupy a considerable space. Bacillus subtilis has been the model of Firmicutes for decades and its genome has been a reference for more than 10 years. Sequencing the genome involved more than 30 laboratories, with different expertises, in a attempt to make the most of the experimental information that could be associated with the sequence. This had the expected drawback that the sequencing expertise was quite varied among the groups involved, especially at a time when sequencing genomes was extremely hard wor

SUBMITTER: Barbe V 

PROVIDER: S-EPMC2885750 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature