Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity.

ABSTRACT:

Objective

Increased risk of cancer and other adult diseases have been associated with perinatal exposure to adverse conditions such as stress and famine. Recently, Insulin-like growth factor II (IGF-II) was identified as the first gene associated with altered expression caused by fetal exposure to poor nutrition. IGF-II regulates fetal development and breast cancer cell survival, in part, by regulating anti-apoptotic proteins through activation of the IGF-I and insulin receptors. African-American (AA) women have a lower overall breast cancer (BC) incidence, however, they present with advanced disease at diagnosis, poorer prognosis and lower survival than Caucasian (CA) women. The reasons for the BC survival disparity are not well understood. We hypothesize that IGF-II plays a role

SUBMITTER: Kalla Singh S 

PROVIDER: S-EPMC2885869 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature