Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.

ABSTRACT: In the kidney, defects in the regulation of urine salt excretion can result in extracellular fluid volume expansion, leading to salt-sensitive hypertension. Previous studies have demonstrated that, when rats are maintained on a high sodium chloride (NaCl) diet, adenosine production increases in the renal medulla with parallel changes in adenosine receptor expression. These studies suggest that adenosine signaling in the kidney can respond to high NaCl loading; however, the functional consequences of these changes in adenosine signaling are not clear. We used the immortalized cell line mIMCD-K2, a murine model system for the renal inner medullary collecting duct, to study the direct effects of adenosine on NaCl transport across the inner medullary collecting duct epithelium with an Ussing c

SUBMITTER: Rajagopal M 

PROVIDER: S-EPMC2885947 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature