Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins.

ABSTRACT: Understanding the mechanisms by which stem cells home precisely to regions of injury or degeneration is of importance to both basic and applied regenerative medicine. Optimizing regenerative processes may depend on identifying the range of molecules that subserve stem cell trafficking. The "rolling" of extravasating cells on endothelium under conditions of physiological flow is the first essential step in the homing cascade and determines cell adhesion and transmigration. Using a laminar flow chamber to simulate physiological shear stress, we explored an aspect of this process by using human neural stem cells (hNSCs). We observed that the interactions between hNSCs and tumor necrosis factor-alpha (TNF-alpha)-stimulated human endothelium (simulating an inflamed milieu) are mediated by a sub

SUBMITTER: Mueller FJ 

PROVIDER: S-EPMC2885956 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature