Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans.

ABSTRACT: The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated with anhedonic symptoms of depression. To investigate whether TREK1 genetic variation influences reward processing, we genotyped healthy individuals (n = 31) who completed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). Three genotypes previously linked to positive antidepressant response were associated with potentiated basal ganglia activity to gains, but did not influence responses to penalties or no change feedback. TREK1 genetic variat

SUBMITTER: Dillon DG 

PROVIDER: S-EPMC2885957 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature