Prefrontal activation deficits during episodic memory in schizophrenia.

ABSTRACT:

Objective

Episodic memory impairments represent a core deficit in schizophrenia that severely limits patients' functional outcome. This quantitative meta-analysis of functional imaging studies of episodic encoding and retrieval tests the prediction that these deficits are most consistently associated with dysfunction in the prefrontal cortex.

Method

Activation likelihood estimation (ALE) was used to perform a quantitative meta-analysis of functional imaging studies that contrasted patients with schizophrenia and healthy volunteers during episodic encoding and retrieval. From a pool of 36 potential studies, 18 whole-brain studies in standard space that included a healthy comparison sample and low-level baseline contrast were selected.

Results

As predicted, patients sho

SUBMITTER: Ragland JD 

PROVIDER: S-EPMC2885958 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature