Ontology highlight
ABSTRACT:
SUBMITTER: Kanhere A
PROVIDER: S-EPMC2886029 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20100601 5
Polycomb proteins maintain cell identity by repressing the expression of developmental regulators specific for other cell types. Polycomb repressive complex-2 (PRC2) catalyzes trimethylation of histone H3 lysine-27 (H3K27me3). Although repressed, PRC2 targets are generally associated with the transcriptional initiation marker H3K4me3, but the significance of this remains unclear. Here, we identify a class of short RNAs, approximately 50-200 nucleotides in length, transcribed from the 5' end of p ...[more]