Neurocognitive functioning in adult survivors of childhood non-central nervous system cancers.

ABSTRACT: BACKGROUND We sought to measure self-reported neurocognitive functioning among survivors of non-central nervous system (CNS) childhood cancers, overall and compared with a sibling cohort, and to identify factors associated with worse functioning. METHODS In a retrospective cohort study, 5937 adult survivors of non-CNS cancers and 382 siblings completed a validated neuropsychological instrument with subscales in task efficiency, emotional regulation, organization, and memory. Scores were converted to T scores; scores in the worst 10% of siblings' scores (ie, T score > or =63) were defined as impaired. Non-CNS cancer survivors and siblings were compared with multivariable linear regression and log-binomial regression. Among survivors, log-binomial models assessed the association of patient a

SUBMITTER: Kadan-Lottick NS 

PROVIDER: S-EPMC2886093 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature