Human bone marrow stromal cells display variable anatomic site-dependent response and recovery from irradiation.

ABSTRACT:

Objectives

Orofacial bone is commonly affected by osteoradionecrosis (ORN) during head and neck cancer radiotherapy possibly due to interactions of several factors including radiation damage to resident bone marrow stromal cells (BMSCs). Irradiation causes DNA damage, triggers p53-dependent signalling resulting in either cell-cycle arrest or apoptosis. In same individuals, disproportionately higher rapid growth of orofacial BMSCs relative to those of axial/appendicular bones suggests their response to radiation is skeletally site-specific. We hypothesised that survival and osteogenic recovery capacity of irradiated human BMSCs is site-dependent based on anatomic skeletal site of origin.

Methods

Early passage BMSCs from maxilla, mandible and iliac crest of four normal volunte

SUBMITTER: Damek-Poprawa M 

PROVIDER: S-EPMC2886662 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature