Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.

ABSTRACT: A low maximal oxygen consumption (VO2max) is a strong risk factor for premature mortality. Supervised endurance exercise training increases VO2max with a very wide range of effectiveness in humans. Discovering the DNA variants that contribute to this heterogeneity typically requires substantial sample sizes. In the present study, we first use RNA expression profiling to produce a molecular classifier that predicts VO2max training response. We then hypothesized that the classifier genes would harbor DNA variants that contributed to the heterogeneous VO2max response. Two independent preintervention RNA expression data sets were generated (n=41 gene chips) from subjects that underwent supervised endurance training: one identified and the second blindly validated an RNA expression signature th

SUBMITTER: Timmons JA 

PROVIDER: S-EPMC2886694 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature