CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells.

ABSTRACT:

Background

Immunotherapeutic strategies to stimulate anti-tumor immunity are promising approaches for cancer treatment. A major barrier to their success is the immunosuppressive microenvironment of tumors, which inhibits the functions of endogenous dendritic cells (DCs) that are necessary for the generation of anti-tumor CD8+ T cells. To overcome this problem, autologous DCs are generated ex vivo, loaded with tumor antigens, and activated in this non-suppressive environment before administration to patients. However, DC-based vaccines rarely induce tumor regression.

Methodology/principal findings

We examined the fate and function of these DCs following their injection using murine models, in order to better understand their interaction with the host immune system. Contrary t

SUBMITTER: Yewdall AW 

PROVIDER: S-EPMC2886840 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature