Preadmission statin use and one-year mortality among patients in intensive care - a cohort study.

ABSTRACT:

Introduction

Statins reduce risk of cardiovascular events and have beneficial pleiotropic effects; both may reduce mortality in critically ill patients. We examined whether statin use was associated with risk of death in general intensive care unit (ICU) patients.

Methods

Cohort study of 12,483 critically ill patients > 45 yrs of age with a first-time admission to one of three highly specialized ICUs within the Aarhus University Hospital network, Denmark, between 2001 and 2007. Statin users were identified through population-based prescription databases. We computed cumulative mortality rates 0-30 days and 31-365 days after ICU admission and mortality rate ratios (MRRs), using Cox regression analysis controlling for potential confounding factors (demographics, use of other c

SUBMITTER: Christensen S 

PROVIDER: S-EPMC2887131 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature