HLA-associated immune pressure on Gag protein in CRF01_AE-infected individuals and its association with plasma viral load.

ABSTRACT:

Background

The human leukocyte antigen (HLA)-restricted cytotoxic T-lymphocyte (CTL) immune response is one of the major factors determining the genetic diversity of human immunodeficiency virus (HIV). There are few population-based analyses of the amino acid variations associated with the host HLA type and their clinical relevance for the Asian population. Here, we identified HLA-associated polymorphisms in the HIV-1 CRF01_AE Gag protein in infected married couples, and examined the consequences of these HLA-selected mutations after transmission to HLA-unmatched recipients.

Methodology/principal findings

One hundred sixteen HIV-1-infected couples were recruited at a government hospital in northern Thailand. The 1.7-kb gag gene was amplified and directly sequenced. We identi

SUBMITTER: Gesprasert G 

PROVIDER: S-EPMC2887364 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature