Vascular Origins of BOLD and CBV fMRI Signals: Statistical Mapping and Histological Sections Compared.

ABSTRACT: Comparison of 3T blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) activation maps to histological sections enables the spatial discrimination of functional magnetic resonance imaging (fMRI) signal changes into different vascular compartments. We use a standard gradient echo-echo planar imaging technique to measure BOLD signal changes in the somatosensory cortex in response to whisker stimulation. Corresponding changes in CBV were estimated following the infusion of a super-paramagnetic contrast agent. We imaged in a tangential imaging plane that covered the cortical surface. Images were associated with post mortem histological sections showing both the surface vasculature and cytochrome oxidase stained whisker barrel cortex. We found a significant BOLD signal change

SUBMITTER: Kennerley AJ 

PROVIDER: S-EPMC2887650 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature