Analysis of structured and intrinsically disordered regions of transmembrane proteins.

ABSTRACT: Integral membrane proteins display two major types of transmembrane structure, helical bundles and beta barrels. The main functional roles of transmembrane proteins are the transport of small molecules and cell signaling, and sometimes these two roles are coupled. For cytosolic, water-soluble proteins, signaling and regulatory functions are often carried out by intrinsically disordered regions. Our long range goal is to determine whether integral membrane proteins likewise use disordered regions for signaling and regulation. Here we carried out a systematic bioinformatics investigation of intrinsically disordered regions obtained from integral membrane proteins for which crystal structures have been determined, and for which the intrinsic disorder was identified as missing electron density

SUBMITTER: Xue B 

PROVIDER: S-EPMC2887740 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature