Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data.

ABSTRACT: Deciphering transcription factor networks from microarray data remains difficult. This study presents a simple method to infer the regulation of transcription factors from microarray data based on well-characterized target genes. We generated a catalog containing transcription factors associated with 2720 target genes and 6401 experimentally validated regulations. When it was available, a distinction between transcriptional activation and inhibition was included for each regulation. Next, we built a tool (www.tfacts.org) that compares submitted gene lists with target genes in the catalog to detect regulated transcription factors. TFactS was validated with published lists of regulated genes in various models and compared to tools based on in silico promoter analysis. We next analyzed the NC

SUBMITTER: Essaghir A 

PROVIDER: S-EPMC2887972 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature