Initiation of simple and complex spikes in cerebellar Purkinje cells.

ABSTRACT: Cerebellar Purkinje cells produce two distinct forms of action potential output: simple and complex spikes. Simple spikes occur spontaneously or are driven by parallel fibre input, while complex spikes are activated by climbing fibre input. Previous studies indicate that both simple and complex spikes originate in the axon of Purkinje cells, but the precise location where they are initiated is unclear. Here we address where in the axon of cerebellar Purkinje cells simple and complex spikes are generated. Using extracellular recording and voltage-sensitive dye imaging in rat and mouse Purkinje cells, we show that both simple and complex spikes are generated in the proximal axon, 15-20 mum from the soma. Once initiated, simple and complex spikes propagate both down the axon and back into the

SUBMITTER: Palmer LM 

PROVIDER: S-EPMC2887989 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature