Expression of the sarA family of genes in different strains of Staphylococcus aureus.

ABSTRACT: Expression of genes involved in the pathogenesis of Staphylococcus aureus is controlled by global regulatory loci, including two-component regulatory systems and transcriptional regulators. The staphylococcal-specific SarA family of transcription regulators control large numbers of target genes involved in virulence, autolysis, biofilm formation, stress responses and metabolic processes, and are recognized as potential therapeutic targets. Expression of some of these important regulators has been examined, mostly in laboratory strains, while the pattern of expression of these genes in other strains, especially clinical isolates, is largely unknown. In this report, a comparative analysis of 10 sarA-family genes was conducted in six different S. aureus strains, including two laboratory (RN63

SUBMITTER: Ballal A 

PROVIDER: S-EPMC2888119 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature