Ontology highlight
ABSTRACT:
SUBMITTER: Gurzov EN
PROVIDER: S-EPMC2888402 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Gurzov Esteban N EN Germano Carla M CM Cunha Daniel A DA Ortis Fernanda F Vanderwinden Jean-Marie JM Marchetti Piero P Zhang Lin L Eizirik Decio L DL
The Journal of biological chemistry 20100426 26
Type 1 diabetes is an autoimmune disorder characterized by chronic inflammation and pancreatic beta-cell loss. Here, we demonstrate that the proinflammatory cytokine interleukin-1beta, combined with interferon-gamma, induces the expression of the Bcl-2 homology 3 (BH3)-only activator PUMA (p53 up-regulated modulator of apoptosis) in beta-cells. Transcriptional activation of PUMA is regulated by nuclear factor-kappaB and endoplasmic reticulum stress but is independent of p53. PUMA activation lead ...[more]