Multiscale model for the assessment of autonomic dysfunction in human endotoxemia.

ABSTRACT: Severe injury and infection are associated with autonomic dysfunction. The realization that a dysregulation in autonomic function may predispose a host to excessive inflammatory processes has renewed interest in understanding the role of central nervous system (CNS) in modulating systemic inflammatory processes. Assessment of heart rate variability (HRV) has been used to evaluate systemic abnormalities and as a predictor of the severity of illness. Dissecting the relevance of neuroimmunomodulation in controlling inflammatory processes requires an understanding of the multiscale interplay between CNS and the immune response. A vital enabler in that respect is the development of a systems-based approach that integrates data across multiple scales, and models the emerging host response as the

SUBMITTER: Foteinou PT 

PROVIDER: S-EPMC2888557 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature